Proximal humerus chondrosarcoma.Long-term clinical and oncological outcomes. / Condrosarcoma de húmero proximal. Resultados clínicos y oncológicos a largo plazo.

INTRODUCTION: The proximal humerus is a common site for primary bone sarcomas, of which chondrosarcoma represents 15%. There are few reports about this select group of tumours. We set out to analyse a group of patients with proximal humerus chondrosarcoma treated with surgery and to assess their long term surgical and oncological outcomes. MATERIAL AND METHODS: A retrospective review was performed and all patients with a proximal humerus chondrosarcoma treated with surgery were included in the study. Overall survival and local recurrence rates were analyzed. Post-operative complications were recorded and limb salvage surgery failures classified according to the Henderson classification. RESULTS: 37 patients were included in the study. The median age was 46 years (SD: 15.6, range: 17-24), 24 (65%) were female and the mean follow-up was 8.5 years (SD: 6.4, range: 2 -26). Eighteen patients were classified as grade 1 (49%), 15 as grade 2 (40%), 2 as grade 3 (5%) and 2 dedifferentiated chondrosarcomas (5%). The 10-year overall survival was 94.5% and the 10-year event-free survival was 84.5%. Five patients developed local recurrences (13%) and none of them was grade 1. The reconstruction failure rate was 27% at 5 years and 34% at 10 years. There were no complications or local recurrence in patients treated with curettage. CONCLUSION: Proximal humerus chondrosarcoma presented high survival rates. Curettage and bone grafting is a safe procedure, with low risk of complications and local recurrence for grade 1 chondrosarcomas and should be the first indication for the proximal humerus. Reconstruction of the proximal humerus after a wide resection has a 5-year failure rate of 27% and 10-year failure rate of 34%.

In Vitro Comparative Study Between Conventional and Computer-Assisted Surgery Methods for Planning and Resection of Bone Sarcomas.

This poster aims to achieve an "in vitro" comparative study between three methods: 2D digital images planning and execution without navigation (freehand with ruler and caliper), 3D planning and execution without navigation (freehand with ruler and caliper) and 3D planning and execution guided with navigation. 3D planning and navigated procedures potentially improve sarcoma resection.

Structural allograft reconstruction of the foot and ankle after tumor resections.

BACKGROUND: Structural allografts have been used to correct deformities or to fill bone defects secondary to tumor excisions, trauma, osteochondral lesions, or intercalary arthrodesis. However, the quality of published evidence supporting the use of allograft transplantation in foot and ankle surgery has been reported as fair. The purpose of this study was to report the overall survival of structural allograft in the foot and ankle after tumor resection, and the survival according to the type of allograft and the complication rates in the medium to long term. MATERIALS AND METHODS: From January 1989 to June 2011, 44 structural allograft reconstructions of the foot and ankle were performed in 42 patients (28 men and 14 women) due to musculoskeletal tumor resections. Mean age at presentation was 27 years. Mean follow-up was 53 months. Demographic data, diagnosis, site of the neoplasm, operations performed, operative complications, outcomes after surgery, date of last follow-up evaluation, and local recurrences were reviewed for all patients. Regarding the type of 44 allograft reconstructions, 16 were hemicylindrical allografts (HA), 12 intercalary allografts (IA), 10 osteoarticular allografts (OA), and 6 were total calcaneal allograft (CA). RESULTS: The overall allograft survival rate, as calculated with the Kaplan-Meier method, at 5 and 10 years was 79 % (95 % CI 64-93 %). When allocated by type of allograft reconstruction the specific allograft survival at 5 and 10 years was: 83 % for CA, 80 % for HA, 77 % for OA, and 75 % for IA. The complications rate for this series was 36 % including: articular failure, local recurrence, infection, fracture and nonunion. CONCLUSION: This study showed that structural allograft reconstruction in the foot and ankle after tumor resection may be durable with a 79 % survival rate at 5 and 10 years. The two types of allografts that showed better survival rate were hemicylindrical allografts (80 %) and calcaneus allografts (83 %). The highest complication rates occurred after calcaneus allografts and osteoarticular allografts. LEVEL OF EVIDENCE: IV.

Oncologic and clinical outcomes in pelvic primary bone sarcomas treated with limb salvage surgery.

PURPOSE: We propose to study a group of patients with primary bone sarcoma of the pelvis treated with limb salvage surgery and analyze overall survival, local recurrence rates and functional outcomes. METHODS: A retrospective review was performed, and all patients diagnosed with pelvic primary bone sarcomas between 1990 and 2012 were analyzed. Patients treated with limb salvage surgery and with a minimum of 12-month follow-up for patients alive were included. The overall survival and the local recurrence rate were calculated for the assessment of oncological results. The associations with gender, age, histological grade, type of surgery, margins chemotherapy response and use of navigation were examined. RESULTS: Fifty-two patients were included in the study. The mean age was 37 years (range 10-82), and mean follow-up was 44 months (range 8-189). Forty-five (86 %) tumors were histologically classified as high-grade sarcomas, four (8 %) as low-grade sarcomas and three (6 %) as dedifferentiated sarcomas. Cancer-specific overall survival was 37.5 % for 5 years and 31 % for 10 years. Local recurrence rate was 30 %. High-grade tumors and chemotherapy necrosis below 90 % were negative prognosis factor. Postoperative complication rate was 34.5 % (n:18), being deep infection the most prevalent (n:13). Reconstruction of the pelvis after an oncology resection for primary pelvic sarcomas increased the incidence of complication significantly (p < 0.001). CONCLUSION: Primary bone sarcomas involving the pelvis are suggestive of a high-grade tumor and present poor oncologic outcomes. Pelvic reconstruction after a limb salvage surgery is associated with a high risk of complication. LEVEL OF EVIDENCE: Case series, Level IV.

Tratamiento quirúrgico de los tumores malignos y localmente agresivos del tercio proximal del peroné. Resultados oncológicos y evaluación funcional / Surgical treatment of locally aggressive and malignant tumors of the proximal third of the fibula. Oncology results and functional evaluation

Introducción. Los tumores óseos malignos o benignos localmente agresivos del tercio proximal del peroné son infrecuentes y generalmente su tratamiento es quirúrgico. Cuando se requiere una resección en bloque, la estabilidad de la rodilla puede comprometerse por afectación del complejo posterolateral. Material y métodos. Se analizaron 28 pacientes operados de manera consecutiva por un tumor óseo en el tercio proximal de peroné entre los años 1980 y 2006 (osteosarcoma: 9, TCG: 9, sarcoma de Ewing: 8 y condrosarcoma: 2). El 61% eran varones y la edad media fue de 21 años (rango: 8-60). El seguimiento promedio fue de 86 meses. El complejo posterolateral fue reinsertado a nivel de la metáfisis tibial. Los pacientes fueron evaluados funcionalmente con la escala Musculoskeletal Tumor Society (MSTS). Resultados. La supervivencia global fue del 89%, con un índice de recidiva local del 11% y un porcentaje de amputaciones secundarias del 6% a los 7 años de seguimiento promedio. El resultado promedio del MSTS fue del 93%. Cinco pacientes sufrieron secuelas neurológicas, 3 de tipo permanente. Ningún paciente sufrió inestabilidad subjetiva ni insuficiencia vascular. Conclusiones. La resección en bloque del peroné proximal en el tratamiento de los tumores óseos agresivos o malignos depara un buen control local de la enfermedad y una supervivencia a los 7 años, en los casos malignos, del 89%. La reinserción del complejo posterolateral a nivel tibial supone una buena estabilidad de la rodilla, sin secuelas funcionales a largo plazo (AU)

Introduction. Proximal fibula malignant and locally aggressive benign bone tumors are uncommon and usually treat by surgery. Bloc resection of the knee can compromise knee stability due to of the resection of the posterolateral ligament complex. Material and methods. We analyzed 28 consecutive patients treated for a proximal fibula bone tumor between 1980 and 2006 (osteosarcoma: 9, giant cell tumor: 9, Ewing sarcoma: 8 and chondrosarcoma: 2). Sixty-one percent were male and the median age was 21 years (range: 8-60). The mean follow-up was 86 months. The posterolateral complex was reinserted at tibial metaphyseal level. Patients were evaluated functionally using the Musculoskeletal Tumor Society scale (MSTS). Results. Overall survival rate was 89%, local recurrence rate was 11%, and secondary amputation rate was 6% at 7 years of median follow-up. The average MSTS score was 93%. Five patients had neurological complications. No patient experienced subjective instability or vascular insufficiency. Conclusions. Bloc resection of the proximal fibula for the treatment of aggressive or malignant primary bone tumors allowed us to obtain local tumor control, and overall survival rate for sarcomas of 89% at 7 years. The posterolateral ligament complex tibial reinsertion provided functional knee stability without major functional consequences in the medium term (AU)

[Surgical treatment of locally aggressive and malignant tumors of the proximal third of the fibula. Oncology results and functional evaluation]. / Tratamiento quirúrgico de los tumores malignos y localmente agresivos del tercio proximal del peroné. Resultados oncológicos y evaluación funcional.

INTRODUCTION: Proximal fibula malignant and locally aggressive benign bone tumors are uncommon and usually treat by surgery. Bloc resection of the knee can compromise knee stability due to of the resection of the posterolateral ligament complex. MATERIAL AND METHODS: We analyzed 28 consecutive patients treated for a proximal fibula bone tumor between 1980 and 2006 (osteosarcoma: 9, giant cell tumor: 9, Ewing sarcoma: 8 and chondrosarcoma: 2). Sixty-one percent were male and the median age was 21 years (range: 8-60). The mean follow-up was 86 months. The posterolateral complex was reinserted at tibial metaphyseal level. Patients were evaluated functionally using the Musculoskeletal Tumor Society scale (MSTS). RESULTS: Overall survival rate was 89%, local recurrence rate was 11%, and secondary amputation rate was 6% at 7 years of median follow-up. The average MSTS score was 93%. Five patients had neurological complications. No patient experienced subjective instability or vascular insufficiency. CONCLUSIONS: Bloc resection of the proximal fibula for the treatment of aggressive or malignant primary bone tumors allowed us to obtain local tumor control, and overall survival rate for sarcomas of 89% at 7 years. The posterolateral ligament complex tibial reinsertion provided functional knee stability without major functional consequences in the medium term.

Bone tumor resection: analysis about 3D preoperative planning and navigation method using a virtual specimen.

The use of three-dimensional preoperative planning and bone tumor resection guided by navigation has increased in the last ten years. However, no study to date, as far as we know, has directly provided evidence of accuracy of this method. The objective of this study was to describe a method capable of determining the accuracy of osteotomies performed for tumor resection planned and guided by navigation. We hypothesize that matching the 3D reconstructed surgical specimen is an acceptable method to determine the accuracy of virtual planning and navigation. A total of seven patients and 14 osteotomies were evaluated. After surgery, all surgical specimens were 3D reconstructed from CT images. The mean of quantitative comparisons between osteotomies planned and osteotomies obtained through the resected specimen was in a global mean of 1.56 millimeters (SD: 2.91) for all the cases. Based on our observations, a three-dimensional model obtained from the tumor surgical specimen is a useful tool to determine accuracy of 3D planning and surgical navigation.

Magnetic resonance imaging follow-up study of bone bruises associated with anterior cruciate ligament ruptures.

PURPOSE: The purpose of this study was to perform a magnetic resonance imaging (MRI) follow-up study of bone bruises in a group of patients with acute anterior cruciate ligament (ACL) ruptures that were reconstructed and followed-up for a minimum of 2 years. TYPE OF STUDY: Cohort study. METHODS: The study group included 21 patients with a mean age of 31 years whose initial MRI scans showed associated bone bruises. Patients were included if they had an acute isolated ACL tear, no documentation of an episode of repeated injury to the affected knee during the follow-up period, and no evidence of cartilaginous injury at the time of arthroscopy. All patients had preoperative MRI scans and underwent arthroscopic ACL reconstruction using a bone-patellar tendon autograft an average of 2 months after injury. The preoperative MRI scans were analyzed using a 3-level grading system based on the appearance and location of bone bruises. A second MRI of the knee was obtained from 24 to 64 months postoperatively (average 34 months). The presence of resolution of bone bruises was determined and correlation with clinical scoring established. RESULTS: This study showed resolution of all type I lesions and 91% of type II lesions (10 of 11). In all type III lesions, an articular cartilage thinning and depression was observed after 2 years of follow-up. In 15 patients (71%), MRI showed that the bone bruises had resolved without apparent sequelae. In the remaining 6 patients (29%), sequelae of the osteochondral lesion were evident on MRI. CONCLUSIONS: According to our clinical data, there was no correlation between scores obtained from patients with resolved lesions against those with osteochondral sequelae. Although long-term clinical implications of these findings are uncertain, a severe occult osteochondral lesion sustained at the time of ACL rupture seems to be persistent on MRI even after a successful reconstruction.

Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee.

Diagnosis of localized pigmented villonodular synovitis is clinically difficult, and plain radiographs are usually normal. This article presents five patients with localized pigmented villonodular synovitis of the knee. Symptoms suggested a meniscal lesion in three patients and a loose body in two. Magnetic resonance imaging performed prior to arthroscopic resection revealed a preoperative diagnosis of a tumor in all five patients. Magnetic resonance imaging is a valuable clinical tool for the assessment of intra-articular soft-tissue tumors of the knee that may otherwise be misdiagnosed.

Survivorship and radiographic analysis of knee osteoarticular allografts.

An evaluation of long-term survival and radiographic deterioration of 118 knee osteoarticular allografts in 114 patients was performed. Radiographic analysis was done according to the Musculoskeletal Tumor Society grading system. A failure was defined as when the allograft was removed during a revision procedure or amputation. Ten patients were lost to followup during the first 2 years after surgery. Eighteen patients without allograft failures died of complications related to the tumor. Twenty-six allografts failed because of infection (13 allografts), local recurrence (eight allografts), massive resorptions (three allografts) and fractures (two allografts). Sixty-four allografts still were in place at a mean of 98 months (range, 36-360 months) after implantation. The Kaplan-Meier 5-year survival rate for the knee osteoarticular allografts was 73% and the limb preservation rate was 93%. The mean radiographic score was 83%. Sixty-four percent of the allografts showed no radiologic changes or minor articular deterioration. Fourteen percent had narrowing of the joint space of more than 2 mm, and 22% had some form of subchondral bone collapse. Five patients required joint resurfacing to preserve the original allograft. Most of the allograft failures occurred during the first 4 years, and the allograft survival rate for the current series remained unchanged after 5 years.

Injuries to polo riders: a prospective evaluation.

OBJECTIVE: To assess prospectively the incidence, nature, and severity of injuries to polo riders competing in the 1996 Argentine High Polo season. METHODS: Assessment, documentation, and provision of care for all injuries sustained during the 1996 season by one of the authors. Riders were also surveyed retrospectively for their previous polo injuries. RESULTS: 34 riders took part in the study. Nine injuries were sustained prospectively and 55 injuries were reviewed retrospectively (64 total). The injuries were categorised as minor (10), moderate (13), and major (41). Twenty five (39%) injuries occurred in the arms, 20 (31%) in the legs, 12 (19%) in the head, 3 (5%) in the back, and 4 (6%) in the face. A fracture occurred in 25 (39%) injuries as most resulted from a fall from the horse. Additionally, facial lacerations occurred prospectively in five riders but did not result in missed play. An overall injury rate of 7.8/1000 player-game hours was calculated. CONCLUSIONS: Although many sports have injury rates much greater than 8/1000 player-game hours, the severity of most injuries occurring in polo was classified as major, with fractures and facial lacerations common. The use of a helmet with a face protector is recommended to decrease injury to players. A doctor experienced in the management of serious trauma should be present at all polo matches.

Posibles lesiones osteocondrales asociadas con lesión del ligamento cruzado anterior: evaluación clínica y con resonancia magnética a los 34 meses / Potential osteochondral lesions associated with anterior cruciate ligament rupture: clinical and MRI evaluation after 34 months

Las lesiones osteocondrales (OC) no reveladas por los estudios radiográficos convencionales (contusiones óseas) han sido descritas mediante resonancia magnética (RM) en un alto porcentaje de los pacientes con lesión aguda del ligamento cruzado anterior (LCA). El objetivo de este estudio prospectivo es el de analizar a un grupo de pacientes con rotura del LCA y lesión OC asociada diagnosticada por RM inicial, evaluándolos en forma clínica y con una segunda RM luego de 2 años de la reconstrucción del LCA. Las lesiones OC fueron clasificadas en las RM pre y posoperatorias en 3 grados, según el aspecto de las imágenes y su relación espacial con la superficie articular: grado I (hemorragia difusa intramedular sin contigüidad con el hueso subcondral), grado II (hemorragia contigua al hueso subcondral) y grado III (depresión o solución de continuidad del contorno de la superficie articular). Fueron evaluados 21 pacientes que presentaban lesiones OC en las RM preoperatorias. Quince (71 por ciento) presentaban resolución de la contusión ósea sin secuela evidente en la RM de control. Los 6 pacientes restantes (29 por ciento) presentaban una secuela de la lesión OC que consistía en disminución del grosor del cartílago articular, depresión de la cortical o defecto osteocondral. De acuerdo con nuestros resultados, las lesiones grados I y II tenderían hacia una resolución espontánea en un alto porcentaje de los casos, por esta razón, en la mayoría de los casos no se debería actuar sobre la lesión condral ni alterarse los protocolos de rehabilitación. Por el contrario, en las lesiones grado III se observa secuela en la RM, en estos casos es factible considerar la conveniencia de un tratamiento preventivo

Posibles lesiones osteocondrales asociadas con lesión del ligamento cruzado anterior: evaluación clínica y con resonancia magnética a los 34 meses / Potential osteochondral lesions associated with anterior cruciate ligament rupture: clinical and MRI evaluation after 34 months

Las lesiones osteocondrales (OC) no reveladas por los estudios radiográficos convencionales (contusiones óseas) han sido descritas mediante resonancia magnética (RM) en un alto porcentaje de los pacientes con lesión aguda del ligamento cruzado anterior (LCA). El objetivo de este estudio prospectivo es el de analizar a un grupo de pacientes con rotura del LCA y lesión OC asociada diagnosticada por RM inicial, evaluándolos en forma clínica y con una segunda RM luego de 2 años de la reconstrucción del LCA. Las lesiones OC fueron clasificadas en las RM pre y posoperatorias en 3 grados, según el aspecto de las imágenes y su relación espacial con la superficie articular: grado I (hemorragia difusa intramedular sin contig³idad con el hueso subcondral), grado II (hemorragia contigua al hueso subcondral) y grado III (depresión o solución de continuidad del contorno de la superficie articular). Fueron evaluados 21 pacientes que presentaban lesiones OC en las RM preoperatorias. Quince (71 por ciento) presentaban resolución de la contusión ósea sin secuela evidente en la RM de control. Los 6 pacientes restantes (29 por ciento) presentaban una secuela de la lesión OC que consistía en disminución del grosor del cartílago articular, depresión de la cortical o defecto osteocondral. De acuerdo con nuestros resultados, las lesiones grados I y II tenderían hacia una resolución espontánea en un alto porcentaje de los casos, por esta razón, en la mayoría de los casos no se debería actuar sobre la lesión condral ni alterarse los protocolos de rehabilitación. Por el contrario, en las lesiones grado III se observa secuela en la RM, en estos casos es factible considerar la conveniencia de un tratamiento preventivo

Osteonecrosis of the knee following arthroscopic meniscectomy in patients over 50-years old.

We reviewed eight patients over 50-years old, with an initial diagnosis of medial meniscal tear confirmed with magnetic resonance imaging (MRI) and with no evidence of osteonecrosis. After arthroscopic meniscectomy, all patients had recurrent aggravated knee pain and reevaluation with MRI showed images compatible with osteonecrosis. The average age was 65 years (range 54 to 75 years). The mean time from MRI to surgery was 8 weeks (range 1 to 28 weeks). In five patients a total meniscectomy, and in three a partial meniscectomy with recontouring of the meniscus were performed. Surgical treatment was initially successful, but all eight patients returned to our office with recurrent aggravated pain in the treated knee. Reevaluation with MRI, at an average of 18 weeks postoperatively, found abnormalities at the medial condyle consistent with osteonecrosis. The purpose of this study is to report a potentially serious outcome after arthroscopic meniscectomy in patients over 50-years old.

Human leukocyte antigen matching, radiographic score, and histologic findings in massive frozen bone allografts.

Forty-six patients receiving frozen bone allografts, preoperatively tissue typed for human leukocyte antigen and ABO antigens, were radiographically evaluated according to the Musculoskeletal Tumor Society scoring system at a mean followup of 55 months. Patients who matched for 1 or 2 Class I human leukocyte antigens with the donor scored higher than patients totally mismatched, but differences were not significant. Matching for Class II human leukocyte antigen and ABO antigens seemed not to influence radiographic outcome of allografts. In sixteen patients histologic specimens were obtained. Five of 16 patients who showed histologic parameters of an immune response scored significantly lower than those who did not. Processed frozen bone allografts, because of their lack of viable donor cells, most likely trigger an indirect pathway of alloantigen recognition in the recipient. This type of recognition may generate in the recipient either a chronic type of rejection or an immunologic state of tolerance to grafted antigens that cannot be measured with human leukocyte antigen blood tests. This may explain difficulties in correlating human leukocyte antigen mismatches between the donor and recipient with frozen bone allograft performances.

Lymphocyte in vitro response to human giant cell tumors.

Peripheral blood lymphocytes and tumor cells were obtained from 31 patients with giant cell tumors of bone and cocultured in vitro in a mixed lymphocyte tumor cell assay. The lymphocyte proliferative response was measured by incorporation of 3H thymidine. Also, the patients' lymphocytes were tested for proliferative reactivity to phytohemagglutinin and allogenic lymphocytes to evaluate nontumor immunologic competence. Mixed lymphocyte tumor cell assays showed higher lymphocyte stimulation in patients with Stage I as compared with Stages II and III giant cell tumors. The proliferative response was blocked partially when the patients' sera was used to supplement the cultures. Lymphocytes from patients with a recurring tumor showed lower responses, but the differences with primary tumors were not significant. This evidence suggests that there is an immune response to giant cell tumor antigens and that this response might be related to the aggressiveness of the tumor.

Localized pigmented villonodular synovitis of the posterior compartment of the knee: diagnosis with magnetic resonance imaging.

Localized Pigmented Villonodular Synovitis (LPVS) is a lesion that may affect any joint but is frequently found in the knee. Detection and diagnosis of this entity are clinically difficult, and plain roentgenograms are usually within normal limits. We present a case report of a LPVS localized at the posterior compartment of the knee that mimics a meniscal lesion. Magnetic resonance imaging (MRI) performed before the resection through an arthroscopic procedure helped to diagnose the tumor, which in this case had an infrequent location. MRI is a valuable clinical tool for the assessment of intraarticular tumors of the knee joint that otherwise may be misdiagnosed and treated as a meniscal tear.

Osteoid osteoma of the hip. Percutaneous resection guided by computed tomography.

Seven patients with a presumptive diagnosis of osteoid osteoma located at the hip were treated with percutaneous resection of the nidus through computed tomography guidance. Histologic confirmation was obtained in 5 of the 7 patients. The average hospital stay was 27 hours. At followup, from 12 to 40 months, all patients remain asymptomatic. This procedure presents potential advantages that traditional open surgery techniques do not have.

The use of a bone allograft for reconstruction after resection of giant-cell tumor close to the knee.

The results of bone-allograft reconstruction after the resection of giant-cell tumor close to the knee were reviewed in fifty-two patients (fifty-five allografts), who had been followed for a mean of seven years (range, two to twenty-four years). One giant-cell tumor was graded as stage 1; twenty, as stage 2; and thirty-one, as stage 3. Three reconstructions were repeated transplants that were done after the failure of a previous transplant. Ten allograft reconstructions were intercalary and were combined with an arthrodesis of the knee, and forty-five were osteoarticular. Major complications included infection (after three reconstructions), resorption of the graft (six), collapse of the articular surface (two), fracture (two), and recurrence (one). According to the criteria described by Mankin et al. for functional analysis, forty-two (76 per cent) of the extremities had a result that was considered to be excellent or good. Radiographic evaluation according to the system of the Musculoskeletal Tumor Society showed a mean score of 72 per cent for osteoarticular reconstructions, and of 86 per cent for intercalary reconstructions.